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EAC can activate the aryl hydrocarbon receptor (AhR), inducing CYP1A1 and CYP1B1 mRNA and protein, and increasing the rate of conversion of PAHs to genotoxic products [65]

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[137] In contrast, the one nicotine inhaler tested did not contain tobacco-specific nitrosamines

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Hence, people often try a small quantity that either they would get a satisfactory product or not